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Inhibition of MRP4 prevents and reverses pulmonary hypertension in mice
Multidrug resistance–associated protein 4 (MRP4, also known as Abcc4) regulates intracellular levels of cAMP and cGMP in arterial SMCs. Here, we report our studies of the role of MRP4 in the development and progression of pulmonary arterial hypertension (PAH), a severe vascular disease characterized...
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| Autori principali: | , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Clinical Investigation
2011
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3223830/ https://ncbi.nlm.nih.gov/pubmed/21670499 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI45023 |
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