Glycogen synthase kinase (GSK)-3 promotes p70 ribosomal protein S6 kinase (p70S6K) activity and cell proliferation

The p70 ribosomal protein S6 kinase 1 (S6K1) plays a key role in cell growth and proliferation by regulating insulin sensitivity, metabolism, protein synthesis, and cell cycle. Thus, deregulation of S6K contributes to the progression of type 2 diabetes, obesity, aging, and cancer. Considering the bi...

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Bibliographic Details
Main Authors: Shin, Sejeong, Wolgamott, Laura, Yu, Yonghao, Blenis, John, Yoon, Sang-Oh
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2011
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PNAS Plus
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3223461/
https://ncbi.nlm.nih.gov/pubmed/22065737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1110195108
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