Low-strength T-cell activation promotes Th17 responses

We show that the strength of T-cell stimulation determines the capability of human CD4(+) T cells to become interleukin-17 (IL-17) producers. CD4(+) T cells received either high- (THi) or low (TLo)–strength stimulation via anti-CD3/CD28 beads or dendritic cells pulsed with superantigen in the presen...

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Main Authors: Purvis, Harriet A., Stoop, Jeroen N., Mann, Jelena, Woods, Steven, Kozijn, Anne E., Hambleton, Sophie, Robinson, John H., Isaacs, John D., Anderson, Amy E., Hilkens, Catharien M. U.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2010
Fag:
Immunobiology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3223073/
https://ncbi.nlm.nih.gov/pubmed/20713963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-03-272153
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