NF-κB–inducing kinase plays an essential T cell–intrinsic role in graft-versus-host disease and lethal autoimmunity in mice

NF-κB–inducing kinase (NIK) is an essential upstream kinase in noncanonical NF-κB signaling. NIK-dependent NF-κB activation downstream of several TNF receptor family members mediates lymphoid organ development and B cell homeostasis. Peripheral T cell populations are normal in the absence of NIK, bu...

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Detalhes bibliográficos
Main Authors: Murray, Susan E., Polesso, Fanny, Rowe, Alexander M., Basak, Soumen, Koguchi, Yoshinobu, Toren, Katelynne Gardner, Hoffmann, Alexander, Parker, David C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3223068/
https://ncbi.nlm.nih.gov/pubmed/22045568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI44943
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