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Novel Inhibitors of Mycobacterium tuberculosis dTDP-6-deoxy-L-lyxo-4-hexulose Reductase (RmlD) Identified by Virtual Screening

The complex and highly impermeable cell wall of Mycobacterium tuberculosis (Mtb) is largely responsible for the ability of the mycobacterium to resist the action of chemical therapeutics. An L-rhamnosyl residue, which occupies an important anchoring position in the Mtb cell wall, is an attractive ta...

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Sonraí Bibleagrafaíochta
Main Authors: Wang, Yi, Hess, Tamara Noelle, Jones, Victoria, Zhou, Joe Zhongxiang, McNeil, Michael R., McCammon, J. Andrew
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2011
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3223023/
https://ncbi.nlm.nih.gov/pubmed/22014548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2011.09.094
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