Bcl-xL enhances single-cell survival and expansion of human embryonic stem cells without affecting self-renewal

Robust expansion and genetic manipulation of human embryonic stem cells (hESCs) and induced-pluripotent stem (iPS) cells are limited by poor cell survival after enzymatic dissociation into single cells. Although inhibition of apoptosis is implicated for the single-cell survival of hESCs, the protect...

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Detalhes bibliográficos
Main Authors: Bai, Hao, Chen, Kang, Gao, Yong-Xing, Arzigian, Melanie, Xie, Yin-Liang, Malcosky, Christopher, Yang, Yong-Guang, Wu, Wen-Shu, Wang, Zack Z.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3222876/
https://ncbi.nlm.nih.gov/pubmed/22099018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.scr.2011.08.002
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