NSD2 links dimethylation of histone H3 at lysine 36 to oncogenic programming

The histone lysine methyltransferase NSD2 (MMSET/WHSC1) is implicated in diverse diseases and commonly overexpressed in multiple myeloma due to a recurrent t(4;14) chromosomal translocation. However, the precise catalytic activity of NSD2 is obscure, preventing progress in understanding how this enz...

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Main Authors: Kuo, Alex J., Cheung, Peggie, Chen, Kaifu, Zee, Barry M., Kioi, Mitomu, Lauring, Josh, Xi, Yuanxin, Park, Ben Ho, Shi, Xiaobing, Garcia, Benjamin A., Li, Wei, Gozani, Or
Format: Artigo
Language:Inglês
Published: 2011
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3222870/
https://ncbi.nlm.nih.gov/pubmed/22099308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2011.08.042
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