Pre-steady-state kinetic analysis of the three Escherichia coli pseudouridine synthases TruB, TruA, and RluA reveals uniformly slow catalysis

Pseudouridine synthases catalyze formation of the most abundant modification of functional RNAs by site-specifically isomerizing uridines to pseudouridines. While the structure and substrate specificity of these enzymes have been studied in detail, the kinetic and the catalytic mechanism of pseudour...

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Bibliographic Details
Main Authors: Wright, Jaden R., Keffer-Wilkes, Laura C., Dobing, Selina R., Kothe, Ute
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory Press 2011
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3222121/
https://ncbi.nlm.nih.gov/pubmed/21998096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.2905811
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