Design and Analysis of Rhesus Cytomegalovirus IL-10 Mutants as a Model for Novel Vaccines against Human Cytomegalovirus

BACKGROUND: Human cytomegalovirus (HCMV) expresses a viral ortholog (CMVIL-10) of human cellular interleukin-10 (cIL-10). Despite only ∼26% amino acid sequence identity, CMVIL-10 exhibits comparable immunosuppressive activity with cIL-10, attenuates HCMV antiviral immune responses, and contributes t...

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Autors principals: Logsdon, Naomi J., Eberhardt, Meghan K., Allen, Christopher E., Barry, Peter A., Walter, Mark R.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2011
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3221699/
https://ncbi.nlm.nih.gov/pubmed/22132227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0028127
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