Activation of Ras Requires the ERM-Dependent Link of Actin to the Plasma Membrane

BACKGROUND: Receptor tyrosine kinases (RTKs) participate in a multitude of signaling pathways, some of them via the small G-protein Ras. An important component in the activation of Ras is Son of sevenless (SOS), which catalyzes the nucleotide exchange on Ras. PRINCIPAL FINDINGS: We can now demonstra...

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Autores principales: Sperka, Tobias, Geißler, Katja J., Merkel, Ulrike, Scholl, Ingmar, Rubio, Ignacio, Herrlich, Peter, Morrison, Helen L.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2011
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3221661/
https://ncbi.nlm.nih.gov/pubmed/22132106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0027511
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