Arginase Inhibition in Airways from Normal and Nitric Oxide Synthase 2-Knockout Mice Exposed to Ovalbumin

Arginase1 and nitric oxide synthase2 (NOS2) utilize L-arginine as a substrate, with both enzymes expressed at high levels in the asthmatic lung. Inhibition of arginase in ovalbumin-exposed C57BL/6 mice with the transition state inhibitor Nω-hydroxy-nor-L-arginine (nor-NOHA) significantly increased t...

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Main Authors: Bratt, Jennifer M., Franzi, Lisa M., Linderholm, Angela L., O’Roark, Erin M., Kenyon, Nicholas J., Last, Jerold A.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3221650/
https://ncbi.nlm.nih.gov/pubmed/19800904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2009.09.018
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