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Expression of the dystrophin isoform Dp116 preserves functional muscle mass and extends lifespan without preventing dystrophy in severely dystrophic mice
Dp116 is a non-muscle isoform of dystrophin that assembles the dystrophin–glycoprotein complex (DGC), but lacks actin-binding domains. To examine the functional role of the DGC, we expressed the Dp116 transgene in mice lacking both dystrophin and utrophin (mdx:utrn(−/−)). Unexpectedly, expression of...
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| Päätekijät: | , , , |
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| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
Oxford University Press
2011
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3221536/ https://ncbi.nlm.nih.gov/pubmed/21949353 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddr433 |
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