Expression of the dystrophin isoform Dp116 preserves functional muscle mass and extends lifespan without preventing dystrophy in severely dystrophic mice

Dp116 is a non-muscle isoform of dystrophin that assembles the dystrophin–glycoprotein complex (DGC), but lacks actin-binding domains. To examine the functional role of the DGC, we expressed the Dp116 transgene in mice lacking both dystrophin and utrophin (mdx:utrn(−/−)). Unexpectedly, expression of...

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Detaylı Bibliyografya
Asıl Yazarlar: Judge, Luke M., Arnett, Andrea L.H., Banks, Glen B., Chamberlain, Jeffrey S.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Oxford University Press 2011
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Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3221536/
https://ncbi.nlm.nih.gov/pubmed/21949353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddr433
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