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A Synthesis of the Tricyclic Core Structure of FR901483 Featuring an Ugi Four-Component Coupling and a Remarkably Selective Elimination Reaction(1)

Three key reactions, an efficient Ugi four-component coupling, a regiospecific, base-mediated elimination reaction, and an intramolecular nitrone/alkene [3+2] cycloaddition, were used to achieve an effective synthesis of the tricyclic molecular framework of the immunosuppressant FR901483. The outcom...

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Autors principals: Seike, Hirofumi, Sorensen, Erik J.
Format: Artigo
Idioma:Inglês
Publicat: 2008
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3221389/
https://ncbi.nlm.nih.gov/pubmed/22114366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1055/s-2008-1042813
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