Functional reconstitution of Haemonchus contortus acetylcholine receptors in Xenopus oocytes provides mechanistic insights into levamisole resistance

BACKGROUND AND PURPOSE: The cholinergic agonist levamisole is widely used to treat parasitic nematode infestations. This anthelmintic drug paralyses worms by activating a class of levamisole-sensitive acetylcholine receptors (L-AChRs) expressed in nematode muscle cells. However, levamisole efficacy...

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Autores principales: Boulin, T, Fauvin, A, Charvet, CL, Cortet, J, Cabaret, J, Bessereau, J-L, Neveu, C
Formato: Artigo
Lenguaje:Inglês
Publicado: Blackwell Publishing Ltd 2011
Materias:
Research Papers
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3221097/
https://ncbi.nlm.nih.gov/pubmed/21486278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2011.01420.x
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