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Target-Decoy Approach and False Discovery Rate: When Things May Go Wrong

The target-decoy approach (TDA) has done the field of proteomics a great service by filling in the need to estimate the false discovery rates (FDR) of peptide identifications. While TDA is often viewed as a universal solution to the problem of FDR evaluation, we argue that the time has come to criti...

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Bibliografische gegevens
Hoofdauteurs: Gupta, Nitin, Bandeira, Nuno, Keich, Uri, Pevzner, Pavel A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2011
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3220955/
https://ncbi.nlm.nih.gov/pubmed/21953092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13361-011-0139-3
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