A SELEX-Screened Aptamer of Human Hepatitis B Virus RNA Encapsidation Signal Suppresses Viral Replication

BACKGROUND: The specific interaction between hepatitis B virus (HBV) polymerase (P protein) and the ε RNA stem-loop on pregenomic (pg) RNA is crucial for viral replication. It triggers both pgRNA packaging and reverse transcription and thus represents an attractive antiviral target. RNA decoys mimic...

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Bibliographic Details
Main Authors: Feng, Hui, Beck, Jürgen, Nassal, Michael, Hu, Kang-hong
Format: Artigo
Language:Inglês
Published: Public Library of Science 2011
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3220704/
https://ncbi.nlm.nih.gov/pubmed/22125633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0027862
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