Coordinated Defects in Hepatic Long Chain Fatty Acid Metabolism and Triglyceride Accumulation Contribute to Insulin Resistance in Non-Human Primates

Non-Alcoholic fatty liver disease (NAFLD) is characterized by accumulation of triglycerides (TG) in hepatocytes, which may also trigger cirrhosis. The mechanisms of NAFLD are not fully understood, but insulin resistance has been proposed as a key determinant. AIMS: To determine the TG content and lo...

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Autori principali: Kamath, Subhash, Chavez, Alberto O., Gastaldelli, Amalia, Casiraghi, Francesca, Halff, Glenn A., Abrahamian, Gregory A., Davalli, Alberto M., Bastarrachea, Raul A., Comuzzie, Anthony G., Guardado-Mendoza, Rodolfo, Jimenez-Ceja, Lilia M., Mattern, Vicki, Paez, Ana Maria, Ricotti, Andrea, Tejero, Mary E., Higgins, Paul B., Rodriguez-Sanchez, Iram Pablo, Tripathy, Devjit, DeFronzo, Ralph A., Dick, Edward J., Cline, Gary W., Folli, Franco
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2011
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3220682/
https://ncbi.nlm.nih.gov/pubmed/22125617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0027617
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