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Ubiquitination in the First Cytoplasmic Loop of μ-Opioid Receptors Reveals a Hierarchical Mechanism of Lysosomal Down-regulation
μ-Type opioid receptors (MORs) are members of the large seven-transmembrane receptor family which transduce the effects of both endogenous neuropeptides and clinically important opioid drugs. Prolonged activation of MORs promotes their proteolytic degradation by endocytic trafficking to lysosomes. T...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Biochemistry and Molecular Biology
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3220576/ https://ncbi.nlm.nih.gov/pubmed/21953467 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.288555 |
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