MicroRNA-18a Enhances the Interleukin-6-mediated Production of the Acute-phase Proteins Fibrinogen and Haptoglobin in Human Hepatocytes

The acute-phase response is an inflammatory process triggered mainly by the cytokine IL-6. Signaling of IL-6 is transduced by activation of STAT3 (signal transducer and activator of transcription 3), which rapidly induces the production of acute-phase proteins such as haptoglobin and fibrinogen. Ano...

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Autors principals: Brock, Matthias, Trenkmann, Michelle, Gay, Renate E., Gay, Steffen, Speich, Rudolf, Huber, Lars C.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2011
Matèries:
Signal Transduction
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3220547/
https://ncbi.nlm.nih.gov/pubmed/21953462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.251793
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