Hydrogen Sulfide and l-Cysteine Increase Phosphatidylinositol 3,4,5-Trisphosphate (PIP3) and Glucose Utilization by Inhibiting Phosphatase and Tensin Homolog (PTEN) Protein and Activating Phosphoinositide 3-Kinase (PI3K)/Serine/Threonine Protein Kinase (AKT)/Protein Kinase Cζ/λ (PKCζ/λ) in 3T3l1 Adipocytes

This work examined the novel hypothesis that reduced levels of H(2)S or l-cysteine (LC) play a role in the impaired glucose metabolism seen in diabetes. 3T3L1 adipocytes were treated with high glucose (HG, 25 mm) in the presence or absence of LC or H(2)S. Both LC and H(2)S treatments caused an incre...

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Hlavní autoři: Manna, Prasenjit, Jain, Sushil K.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2011
Témata:
Metabolism
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3220540/
https://ncbi.nlm.nih.gov/pubmed/21953448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.270884
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