Reactions of the UVRABC excision nuclease with DNA damaged by diamminedichloroplatinum(II).
Mutants of Escherichia coli, which are blocked in excision repair (uvrA6, uvrB5, or uvrC34) are exceptionally sensitive to the antitumor drug cis-Pt(II)(NH3)2Cl2 (cis-DDP) but not the trans isomer. Plasmid DNA, damaged by either the cis or trans compound and treated with the UVRABC excision nuclease...
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| Udgivet i: | Nucleic Acids Res |
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| Principais autores: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Oxford University Press
1985
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| Online adgang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC322051/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3903663/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/13.20.7395 |
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