Genetic Dissection of the Functions of the Melanocortin-3 Receptor, a Seven-transmembrane G-protein-coupled Receptor, Suggests Roles for Central and Peripheral Receptors in Energy Homeostasis

The melanocortin-3 receptor (MC3R) gene is pleiotropic, influencing body composition, natriuresis, immune function, and entrainment of circadian rhythms to nutrient intake. MC3Rs are expressed in hypothalamic and limbic regions of the brain and in peripheral tissues. To investigate the roles of cent...

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Main Authors: Begriche, Karima, Levasseur, Peter R., Zhang, Jingying, Rossi, Jari, Skorupa, Danielle, Solt, Laura A., Young, Brandon, Burris, Thomas P., Marks, Daniel L., Mynatt, Randall L., Butler, Andrew A.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2011
Teme:
Metabolism
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3220494/
https://ncbi.nlm.nih.gov/pubmed/21984834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.278374
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