Structural Analyses of a Purine Biosynthetic Enzyme from Mycobacterium tuberculosis Reveal a Novel Bound Nucleotide

Enzymes of the de novo purine biosynthetic pathway have been identified as essential for the growth and survival of Mycobacterium tuberculosis and thus have potential for the development of anti-tuberculosis drugs. The final two steps of this pathway are carried out by the bifunctional enzyme 5-amin...

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Bibliographic Details
Main Authors: Le Nours, Jérôme, Bulloch, Esther M. M., Zhang, Zhening, Greenwood, David R., Middleditch, Martin J., Dickson, James M. J., Baker, Edward N.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2011
Subjects:
Protein Structure and Folding
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3220471/
https://ncbi.nlm.nih.gov/pubmed/21956117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.291138
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