PD-L1 blockade improves survival in experimental sepsis by inhibiting lymphocyte apoptosis and reversing monocyte dysfunction

INTRODUCTION: Lymphocyte apoptosis and monocyte dysfunction play a pivotal role in sepsis-induced immunosuppression. Programmed death-1 (PD1) and its ligand programmed death ligand-1 (PD-L1) exert inhibitory function by regulating the balance among T cell activation, tolerance, and immunopathology....

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Библиографические подробности
Главные авторы: Zhang, Yan, Zhou, Ying, Lou, Jingsheng, Li, Jinbao, Bo, Lulong, Zhu, Keming, Wan, Xiaojian, Deng, Xiaoming, Cai, Zailong
Формат: Artigo
Язык:Inglês
Опубликовано: BioMed Central 2010
Предметы:
Research
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3220038/
https://ncbi.nlm.nih.gov/pubmed/21118528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/cc9354
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