Early Treatment of NOD Mice With B7-H4 Reduces the Incidence of Autoimmune Diabetes

OBJECTIVE: Autoimmune diabetes is a T cell–mediated disease in which insulin-producing β-cells are destroyed. Autoreactive T cells play a central role in mediating β-cell destruction. B7-H4 is a negative cosignaling molecule that downregulates T-cell responses. In this study, we aim to determine the...

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Detalhes bibliográficos
Main Authors: Wang, Xiaojie, Hao, Jianqiang, Metzger, Daniel L., Mui, Alice, Ao, Ziliang, Akhoundsadegh, Noushin, Langermann, Solomon, Liu, Linda, Chen, Lieping, Ou, Dawei, Verchere, C. Bruce, Warnock, Garth L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2011
Assuntos:
Pathophysiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3219946/
https://ncbi.nlm.nih.gov/pubmed/21984581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db11-0375
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