Blockade of both B7-H4 and CTLA-4 co-signaling pathways enhances mouse islet allograft survival

Costimulation blockade is an effective way to prevent allograft rejection. In this study, we tested the efficacy of two negative co-signaling molecules in protecting islet allograft function. We used local expression of B7-H4 by adenoviral transduction of islets (Ad-B7-H4) and systemic administratio...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Wang, Xiaojie, Hao, Jianqiang, Metzger, Daniel L., Mui, Alice, Lee, I-Fang, Akhoundsadegh, Noushin, Chen, C. Lieping, Ou, Dawei, Ao, Ziliang, Verchere, C. Bruce, Warnock, Garth L.
Format: Artigo
Langue:Inglês
Publié: Landes Bioscience 2012
Sujets:
Research Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3496653/
https://ncbi.nlm.nih.gov/pubmed/22878670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/isl.21239
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