Deficiency for Costimulatory Receptor 4-1BB Protects Against Obesity-Induced Inflammation and Metabolic Disorders

OBJECTIVE: Inflammation is an important factor in the development of insulin resistance, type 2 diabetes, and fatty liver disease. As a member of the tumor necrosis factor receptor superfamily (TNFRSF9) expressed on immune cells, 4-1BB/CD137 provides a bidirectional inflammatory signal through bindi...

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Main Authors: Kim, Chu-Sook, Kim, Jae Geun, Lee, Byung-Ju, Choi, Myung-Sook, Choi, Hye-Sun, Kawada, Teruo, Lee, Ki-Up, Yu, Rina
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2011
Assuntos:
Obesity Studies
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3219944/
https://ncbi.nlm.nih.gov/pubmed/21998397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db10-1805
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