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Is the bithiazole moiety of bleomycin a classical intercalator?

Bleomycin is a widespread anticancerous drug, the biological activity of which having been extensively studied. Its metal ion-chelating portion has been shown to cleave DNA whereas the role of the bithiazole moiety is still questionable. In order to elucidate this problem some 2', 4-disubstitut...

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Bibliografiske detaljer
Main Authors: Hénichart, J P, Bernier, J L, Helbecque, N, Houssin, R
Format: Artigo
Sprog:Inglês
Udgivet: 1985
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC321987/
https://ncbi.nlm.nih.gov/pubmed/2414728
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