Roflumilast attenuates allergen-induced inflammation in mild asthmatic subjects

BACKGROUND: Phosphodiesterase 4 (PDE4) inhibitors increase intracellular cyclic adenosine monophosphate (cAMP), leading to regulation of inflammatory cell functions. Roflumilast is a potent and targeted PDE4 inhibitor. The objective of this study was to evaluate the effects of roflumilast on broncho...

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Bibliographic Details
Main Authors: Gauvreau, Gail M, Boulet, Louis-Philippe, Schmid-Wirlitsch, Christine, Côté, Johanne, Duong, MyLinh, Killian, Kieran J, Milot, Joanne, Deschesnes, Francine, Strinich, Tara, Watson, Richard M, Bredenbröker, Dirk, O'Byrne, Paul M
Format: Artigo
Language:Inglês
Published: BioMed Central 2011
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3219708/
https://ncbi.nlm.nih.gov/pubmed/22029856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1465-9921-12-140
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