Overexpression of Bcl2 in Osteoblasts Inhibits Osteoblast Differentiation and Induces Osteocyte Apoptosis

Bcl2 subfamily proteins, including Bcl2 and Bcl-X(L), inhibit apoptosis. As osteoblast apoptosis is in part responsible for osteoporosis in sex steroid deficiency, glucocorticoid excess, and aging, bone loss might be inhibited by the upregulation of Bcl2; however, the effects of Bcl2 overexpression...

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Auteurs principaux: Moriishi, Takeshi, Maruyama, Zenjiro, Fukuyama, Ryo, Ito, Masako, Miyazaki, Toshihiro, Kitaura, Hideki, Ohnishi, Hidetake, Furuichi, Tatsuya, Kawai, Yosuke, Masuyama, Ritsuko, Komori, Hisato, Takada, Kenji, Kawaguchi, Hiroshi, Komori, Toshihisa
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2011
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3219663/
https://ncbi.nlm.nih.gov/pubmed/22114675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0027487
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