In vivo rescue of alveolar macrophages from SP-A knockout mice with exogenous SP-A nearly restores a wild type intracellular proteome; actin involvement

BACKGROUND: Mice lacking surfactant protein-A (SP-A-/-; knockout; KO) exhibit increased vulnerability to infection and injury. Although many bronchoalveolar lavage (BAL) protein differences between KO and wild-type (WT) are rapidly reversed in KO after infection, their clinical course is still compr...

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Main Authors: Phelps, David S, Umstead, Todd M, Quintero, Omar A, Yengo, Christopher M, Floros, Joanna
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2011
Assuntos:
Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3219558/
https://ncbi.nlm.nih.gov/pubmed/22035134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1477-5956-9-67
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