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Conditional deletion of Pkd1 in osteocytes disrupts skeletal mechanosensing in mice
We investigated whether polycystin-1 is a bone mechanosensor. We conditionally deleted Pkd1 in mature osteoblasts/osteocytes by crossing Dmp1-Cre with Pkd1(flox/m1Bei) mice, in which the m1Bei allele is nonfunctional. We assessed in wild-type and Pkd1-deficient mice the response to mechanical loadin...
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| Autori principali: | , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Federation of American Societies for Experimental Biology
2011
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3219213/ https://ncbi.nlm.nih.gov/pubmed/21454365 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.10-180299 |
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