Conditional deletion of Pkd1 in osteocytes disrupts skeletal mechanosensing in mice

We investigated whether polycystin-1 is a bone mechanosensor. We conditionally deleted Pkd1 in mature osteoblasts/osteocytes by crossing Dmp1-Cre with Pkd1(flox/m1Bei) mice, in which the m1Bei allele is nonfunctional. We assessed in wild-type and Pkd1-deficient mice the response to mechanical loadin...

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Main Authors: Xiao, Zhousheng, Dallas, Mark, Qiu, Ni, Nicolella, Daniel, Cao, Li, Johnson, Mark, Bonewald, Lynda, Quarles, L. Darryl
Format: Artigo
Jezik:Inglês
Izdano: Federation of American Societies for Experimental Biology 2011
Teme:
Research Communications
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3219213/
https://ncbi.nlm.nih.gov/pubmed/21454365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.10-180299
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