Targeted enrichment beyond the consensus coding DNA sequence exome reveals exons with higher variant densities

BACKGROUND: Enrichment of loci by DNA hybridization-capture, followed by high-throughput sequencing, is an important tool in modern genetics. Currently, the most common targets for enrichment are the protein coding exons represented by the consensus coding DNA sequence (CCDS). The CCDS, however, exc...

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Bibliographic Details
Main Authors:	Bainbridge, Matthew N, Wang, Min, Wu, Yuanqing, Newsham, Irene, Muzny, Donna M, Jefferies, John L, Albert, Thomas J, Burgess, Daniel L, Gibbs, Richard A
Format:	Artigo
Language:	Inglês
Published:	BioMed Central 2011
Subjects:	Research
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3218830/ https://ncbi.nlm.nih.gov/pubmed/21787409 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/gb-2011-12-7-r68
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Targeted enrichment beyond the consensus coding DNA sequence exome reveals exons with higher variant densities

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