Targeted enrichment beyond the consensus coding DNA sequence exome reveals exons with higher variant densities

BACKGROUND: Enrichment of loci by DNA hybridization-capture, followed by high-throughput sequencing, is an important tool in modern genetics. Currently, the most common targets for enrichment are the protein coding exons represented by the consensus coding DNA sequence (CCDS). The CCDS, however, exc...

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Autori principali: Bainbridge, Matthew N, Wang, Min, Wu, Yuanqing, Newsham, Irene, Muzny, Donna M, Jefferies, John L, Albert, Thomas J, Burgess, Daniel L, Gibbs, Richard A
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2011
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3218830/
https://ncbi.nlm.nih.gov/pubmed/21787409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/gb-2011-12-7-r68
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