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Improved variant discovery through local re-alignment of short-read next-generation sequencing data using SRMA
A primary component of next-generation sequencing analysis is to align short reads to a reference genome, with each read aligned independently. However, reads that observe the same non-reference DNA sequence are highly correlated and can be used to better model the true variation in the target genom...
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| Hauptverfasser: | , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
BioMed Central
2010
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| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3218665/ https://ncbi.nlm.nih.gov/pubmed/20932289 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/gb-2010-11-10-r99 |
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