Nanoparticulate formulations of mithramycin analogs for enhanced cytotoxicity

Mithramycin (MTM), a natural product of soil bacteria from the Streptomyces genus, displays potent anticancer activity but has been limited clinically by severe side effects and toxicities. Engineering of the MTM biosynthetic pathway has produced the 3-side-chain-modified analogs MTM SK (SK) and MTM...

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Detaylı Bibliyografya
Asıl Yazarlar: Scott, Daniel, Rohr, Jürgen, Bae, Younsoo
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Dove Medical Press 2011
Konular:
Original Research
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3218587/
https://ncbi.nlm.nih.gov/pubmed/22114504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S25427
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