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Nanoparticulate formulations of mithramycin analogs for enhanced cytotoxicity
Mithramycin (MTM), a natural product of soil bacteria from the Streptomyces genus, displays potent anticancer activity but has been limited clinically by severe side effects and toxicities. Engineering of the MTM biosynthetic pathway has produced the 3-side-chain-modified analogs MTM SK (SK) and MTM...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Dove Medical Press
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3218587/ https://ncbi.nlm.nih.gov/pubmed/22114504 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S25427 |
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