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Hydrogen–deuterium exchange in vivo to measure turnover of an ALS-associated mutant SOD1 protein in spinal cord of mice
Mutations of cytosolic Cu/Zn superoxide dismutase 1 (SOD1) in humans and overexpression of mutant human SOD1 genes in transgenic mice are associated with the motor neuron degenerative condition known as amyotrophic lateral sclerosis (ALS; Lou Gehrig's disease). Gain-of-function toxicity from th...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Wiley Subscription Services, Inc., A Wiley Company
2011
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3218362/ https://ncbi.nlm.nih.gov/pubmed/21780215 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.700 |
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