LIV-1 Promotes Prostate Cancer Epithelial-to-Mesenchymal Transition and Metastasis through HB-EGF Shedding and EGFR-Mediated ERK Signaling

LIV-1, a zinc transporter, is an effector molecule downstream from soluble growth factors. This protein has been shown to promote epithelial-to-mesenchymal transition (EMT) in human pancreatic, breast, and prostate cancer cells. Despite the implication of LIV-1 in cancer growth and metastasis, there...

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Autori principali: Lue, Hui-Wen, Yang, Xiaojian, Wang, Ruoxiang, Qian, Weiping, Xu, Roy Z. H., Lyles, Robert, Osunkoya, Adeboye O., Zhou, Binhua P., Vessella, Robert L., Zayzafoon, Majd, Liu, Zhi-Ren, Zhau, Haiyen E., Chung, Leland W. K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2011
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3218022/
https://ncbi.nlm.nih.gov/pubmed/22110740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0027720
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