Distinct Roles of MicroRNA-1 and -499 in Ventricular Specification and Functional Maturation of Human Embryonic Stem Cell-Derived Cardiomyocytes

BACKGROUND: MicroRNAs (miRs) negatively regulate transcription and are important determinants of normal heart development and heart failure pathogenesis. Despite the significant knowledge gained in mouse studies, their functional roles in human (h) heart remain elusive. METHODS AND RESULTS: We hypot...

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Main Authors: Fu, Ji-Dong, Rushing, Stephanie N., Lieu, Deborah K., Chan, Camie W., Kong, Chi-Wing, Geng, Lin, Wilson, Kitchener D., Chiamvimonvat, Nipavan, Boheler, Kenneth R., Wu, Joseph C., Keller, Gordon, Hajjar, Roger J., Li, Ronald A.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3217986/
https://ncbi.nlm.nih.gov/pubmed/22110643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0027417
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