The vitamin E analog, alpha-tocopheryloxyacetic acid enhances the anti-tumor activity of trastuzumab against HER2/neu-expressing breast cancer

BACKGROUND: HER2/neu is an oncogene that facilitates neoplastic transformation due to its ability to transduce growth signals in a ligand-independent manner, is over-expressed in 20-30% of human breast cancers correlating with aggressive disease and has been successfully targeted with trastuzumab (H...

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Main Authors: Hahn, Tobias, Bradley-Dunlop, Deborah J, Hurley, Laurence H, Von-Hoff, Daniel, Gately, Stephen, Mary, Disis L, Lu, Hailing, Penichet, Manuel L, Besselsen, David G, Cole, Brook B, Meeuwsen, Tanisha, Walker, Edwin, Akporiaye, Emmanuel T
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3217981/
https://ncbi.nlm.nih.gov/pubmed/22044845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-11-471
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