Pro1170 Ala polymorphism in HER2-neu is associated with risk of trastuzumab cardiotoxicity

BACKGROUND: Variations in single nucleotide polymorphisms (SNPs) have been associated with enhanced drug efficacy and toxicity in cancer therapy. SNP variations in the ErbB2 gene have been identified that alter the protein sequence of the HER2-neu protein, but how these polymorphisms affect prognosi...

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Bibliografski detalji
Izdano u:BMC Cancer
Glavni autori: Stanton, Sasha E, Ward, Maureen M, Christos, Paul, Sanford, Rachel, Lam, Christina, Cobham, Marta V, Donovan, Diana, Scheff, Ronald J, Cigler, Tessa, Moore, Anne, Vahdat, Linda T, Lane, Maureen E, Chuang, Ellen
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2015
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4403678/
https://ncbi.nlm.nih.gov/pubmed/25885598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-015-1298-6
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