Janus kinase-2 inhibition induces durable tolerance to alloantigen by human dendritic cell–stimulated T cells yet preserves immunity to recall antigen

Janus kinase-2 (JAK2) conveys receptor-binding signals by several inflammatory cytokines, including IL-6, via phosphorylation of signal transducer and activator of transcription 3 (STAT3). We demonstrate that selective JAK2 inhibition by TG101348 during initial encounters between human T cells and a...

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Bibliografiske detaljer
Main Authors: Betts, Brian C., Abdel-Wahab, Omar, Curran, Shane A., St Angelo, Erin T., Koppikar, Priya, Heller, Glenn, Levine, Ross L., Young, James W.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2011
Fag:
Immunobiology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3217413/
https://ncbi.nlm.nih.gov/pubmed/21917753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-06-363408
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