Developmental origins and impact of BCR-ABL1 fusion and IKZF1 deletions in monozygotic twins with Ph(+) acute lymphoblastic leukemia

The timing and developmental sequence of events for BCR-ABL1(+) acute lymphoblastic leukemia (ALL), usually associated with IKAROS (IKZF1) deletions, are unknown. We assessed the status of BCR-ABL1 and IKZF1 genes in 2 pairs of monozygotic twins, one pair concordant, the other discordant for Philade...

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Detalhes bibliográficos
Main Authors: Cazzaniga, Giovanni, van Delft, Frederik W., Lo Nigro, Luca, Ford, Anthony M., Score, Joannah, Iacobucci, Ilaria, Mirabile, Elena, Taj, Mary, Colman, Susan M., Biondi, Andrea, Greaves, Mel
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2011
Assuntos:
Lymphoid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3217357/
https://ncbi.nlm.nih.gov/pubmed/21960589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-07-366542
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