PTEN deficiency in mast cells causes a mastocytosis-like proliferative disease that heightens allergic responses and vascular permeability

Kit regulation of mast cell proliferation and differentiation has been intimately linked to the activation of phosphatidylinositol 3-OH kinase (PI3K). The activating D816V mutation of Kit, seen in the majority of mastocytosis patients, causes a robust activation of PI3K signals. However, whether inc...

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Main Authors: Furumoto, Yasuko, Charles, Nicolas, Olivera, Ana, Leung, Wai Hang, Dillahunt, Sandra, Sargent, Jennifer L., Tinsley, Kevin, Odom, Sandra, Scott, Eric, Wilson, Todd M., Ghoreschi, Kamran, Kneilling, Manfred, Chen, Mei, Lee, David M., Bolland, Silvia, Rivera, Juan
Format: Artigo
Jezik:Inglês
Izdano: American Society of Hematology 2011
Teme:
Immunobiology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3217349/
https://ncbi.nlm.nih.gov/pubmed/21926349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-09-309955
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