Androgen receptor polyglutamine repeat length affects receptor activity and C2C12 cell development

Testosterone (T) has an anabolic effect on skeletal muscle and is believed to exert its local effects via the androgen receptor (AR). The AR harbors a polymorphic stretch of glutamine repeats demonstrated to inversely affect receptor transcriptional activity in prostate and kidney cells. The effects...

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Detalhes bibliográficos
Main Authors: Sheppard, Ryan L., Spangenburg, Espen E., Chin, Eva R., Roth, Stephen M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2011
Assuntos:
Call for Papers: Functional Analysis of Sequence Variation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3217329/
https://ncbi.nlm.nih.gov/pubmed/21828246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/physiolgenomics.00049.2011
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