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Angiotensin II directly induces muscle protein catabolism through the ubiquitin–proteasome proteolytic pathway and may play a role in cancer cachexia

The ability of angiotensin I (Ang I) and II (Ang II) to induce directly protein degradation in skeletal muscle has been studied in murine myotubes. Angiotensin I stimulated protein degradation with a parabolic dose–response curve and with a maximal effect between 0.05 and 0.1 μM. The effect was atte...

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書目詳細資料
Main Authors: Sanders, P M, Russell, S T, Tisdale, M J
格式: Artigo
語言:Inglês
出版: Nature Publishing Group 2005
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3217221/
https://ncbi.nlm.nih.gov/pubmed/16052213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6602725
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