NATb/NAT1*4 promotes greater arylamine N-acetyltransferase 1 mediated DNA adducts and mutations than NATa/NAT1*4 following exposure to 4-aminobiphenyl

N -acetyltransferase 1 (NAT1) is a phase II metabolic enzyme responsible for the biotransformation of aromatic and heterocyclic amine carcinogens such as 4-aminobiphenyl (ABP). NAT1 catalyzes N-acetylation of arylamines as well as the O-acetylation of N-hydroxylated arylamines. O-acetylation leads t...

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Hauptverfasser: Millner, Lori M., Doll, Mark A., Cai, Jian, States, J. Christopher, Hein, David W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3217153/
https://ncbi.nlm.nih.gov/pubmed/21837760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mc.20836
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